In vitro diagnostic reagent heart failure judgment markers

Through in vitro diagnostic reagent, according to the results of the heart failure is a very dangerous diseases will seriously affect people's life and health. So, how to judge the right heart failure will be for the treatment of patients was key. Therefore judge heart failure of the severity of biological markers in the therapy of help. The in vitro diagnostic reagent, the researchers observed heart failure patients breath gas high content of acetone. The aim of the study was to evaluate the breath gas acetone content can as a diagnostic heart failure, and judge its serious degree of biological markers.

     From May 2009 to September 2010 a total of 235 cases of patients with systolic dysfunction, including 89 patients with compliance with this research into the standard (namely hf group), and to the gender and age of the healthy subjects and matching pairs of (control group, n = 20). And according to the clinical hf group unstable, acute decompensated heart failure sex (ADHF, N = 59) and chronic heart failure (ChronHF, N = 30). The participants gathered out gas, by gas chromatography mass spectrometry for qualitative and quantitative spectrophotometric method. Patients with diabetes are out.

     Compared with the control, hf group breath gas high concentrations of acetone, median (iqr) were 3.7 u g/L (1.69-10.45) and 0.39 u g/L (0.30-0.79) (P < 0.001). And compared with chronic heart failure group, acute decompensated heart failure of group breath gas concentration of acetone higher, median (iqr) were 7.8 u g/L (3.6-15.2) and 1.22 u g/L (0.68-2.19) (P < 0.001). This method to diagnose heart failure and acute decompensated heart failure of the accuracy and sensitivity are at about 85%, and plasma b-type natriuretic peptide (BNP) approximation. Meanwhile, New York heart function classification of different patients breath gas concentration of acetone significant difference (P < 0.001), the breath gas concentration can be as heart failure of acetone serious degree of grading sign. In addition, breath gas concentration of acetone and plasma b-type natriuretic peptide levels were positively correlated (R = 0.772, P < 0.001).

      According to in vitro diagnostic reagents research conclusion, breath gas concentration can be the acetone as a noninvasive diagnostic method of heart failure has wide application prospects, and the accuracy and BNP quite, also can be used as heart failure of the severity of new biological markers.